Avi Samelson, PhD

Avi Samelson Kampmann Lab

avi.samelson@ucsf.edu
Postdoctoral Fellow

Education

  • BA Biological Sciences: Biochemistry - Northwestern University (2010)
  • PhD Molecular and Cell Biology: “Biophysical Characterization of Ribosome Nascent Chain Energy Landscapes” - UC Berkeley (2017)

Publications

List of publications on Pubmed

  • Samelson AJ, Jensen MK, Soto RA, Cate JH, Marqusee S. Quantitative determination of ribosome nascent chain stability. Proc Natl Acad Sci U S A. 2016 Nov 22;113(47):13402-13407. Epub 2016 Nov 7. PubMed PMID: 27821780; PubMed Central PMCID: PMC5127326.
  • Chou S, Upton H, Bao K, Schulze-Gahmen U, Samelson AJ, He N, Nowak A, Lu H, Krogan NJ, Zhou Q, Alber T. HIV-1 Tat recruits transcription elongation factors dispersed along a flexible AFF4 scaffold. Proc Natl Acad Sci U S A. 2013 Jan 8;110(2):E123-31. doi: 10.1073/pnas.1216971110. Epub 2012 Dec 18. PubMed PMID: 23251033; PubMed Central PMCID: PMC3545800.
  • Fraser JS, van den Bedem H, Samelson AJ, Lang PT, Holton JM, Echols N, Alber T. Accessing protein conformational ensembles using room-temperature X-ray crystallography. Proc Natl Acad Sci U S A. 2011 Sep 27;108(39):16247-52. doi: 10.1073/pnas.1111325108. Epub 2011 Sep 14. PubMed PMID: 21918110; PubMed Central PMCID: PMC3182744.

Research Interests

The selective vulnerability of neurons and neuronal subtypes to proteostatic stress and protein aggregation continues to be a mystery in the study of neurodegenerative disease, aging, and cellular quality control. I am interested in understanding the interplay between cell-type specific protein quality control and sequence determinants of protein aggregation in vivo using deep mutational scanning and functional genomics approaches.

Other interests

Swimming, hiking, food