Honorary Lab Member
I am currently in my oncology fellowship at UCSF and I am in the postdoctoral research phase of training. In the clinic I take care of patients with gastrointestinal cancers, and I have a specific interest in pancreatic cancer. This is the most devastating cancer with the worst prognosis, and I am very excited to be working in the lab to explore this malignancy at a molecular level to try to find new drug targets for this disease. Many people don’t know that about 10 percent of pancreatic cancer patients are thought to have a hereditary predisposition, however we have not yet identified the majority of the genes that lead to this predisposition. We do know that the BRCA 1 and 2 genes can predispose patients to developing pancreatic cancer, and given the relative frequency of BRCA1/2 mutations in the population, this is a subset of pancreatic cancer that is of great research interest. While we have learned much about targeting the homologous repair defect in BRCA-mutant breast and ovarian cancer, we know less about how to target this defect in the context of pancreatic cancer. I am very excited to be working in the Kampmann lab to harness the power of novel screening platforms to explore specific vulnerabilities in BRCA-mutant pancreatic cancer models. Specifically, I am working on performing a CRISPRi screen on an isogenic pair of pancreatic cancer cell lines with and without a functional BRCA gene. I hope this screen will help us identify new ways to treat a significant subset of pancreatic cancers that harbor DNA-damage repair defects.
- BA, Stanford 2005
- MD, Harvard 2011
- Carnevale J, Ashworth A. Assessing the Significance of BRCA1 and BRCA2 Mutations in Pancreatic Cancer. J Clin Oncol. (2015) May 18.
- Wang C, Carnevale J, Rubenstein JL. Progress in CNS Lymphomas. Br J Haematol. (2014) Aug;166(3):311-25.
- Renella R, Carnevale J, Schneider KA, Hornick JL, Rana H, Janeway K. Exploring the association of succinate dehydrogenase complex mutations with lymphoid malignancies. Fam Cancer. (2014) Sep;13(3):507-11.
- Carnevale J, Ross L, Puissant A, Banerji V, Stone RM, Deangelo DJ, Ross KN, Stegmaier K. Syk Regulates mTOR signaling in AML. Leukemia. (2013) Nov;27(11):2118-28.
- Berman R, Powe C, Carnevale J, Chao A, Knudsen J, Nguyen A, Edgman-Levitan S. The Crimson Care Collaborative: A Student–Faculty Initiative to Increase Medical Students’ Early Exposure to Primary Care. Acad Med. (2012):87;651–655.
- Carnevale J, Gropper A, Agnew-Blais J, Mimiaga M, Mhango A, Bail R, Ngoma M. Knowledge, misconceptions and poor caretaker-child communication about HIV in peri-urban schoolchildren of Lusaka, Zambia. AIDS CARE (2011) May;23(5):646-53.
- Agnew-Blais J, Carnevale J, Gropper A, Shilika E, Bail R, Ngoma M. Schistosomiasis haematobium prevalence and risk factors in a school-age population of peri-urban Lusaka, Zambia. Journal of Tropical Pediatrics (2009) 56(4):247-253.
Awards / Honors:
- 2014 Hematology/Oncology Division Clinical Fellow Award, UCSF: Awarded to the fellow who has demonstrated exceptional patient care, superior knowledge and skill in hematology/oncology as well as outstanding teaching and professionalism.
- 2011 Dr. Bemy Jelin Prize, Harvard Medical School: Awarded to the Harvard Medical School student who most demonstrates academic excellence with career interests in oncology.
- 2011 Krankle Rose Seegal Prize, Harvard Medical School: For the best published paper on the relation of the medical profession to the community.
- 2011 Presidential Scholars Public Service Initiative Award, Harvard Medical School.
- 2011 Graduated Cum Laude, Harvard Medical School: Honors Thesis on Identifying Downstream Targets of SYK in AML
Grants / Fellowships:
- 2014-present T32 Research Award in Molecular and Cellular Mechanisms of Cancer, Awarded to support post-doctoral research.
- 2009-10 Howard Hughes Research Training Fellowship
- Dana Farber Cancer Research Institute, Dr. Kimberly Stegmaier’s laboratory. To research the role of a newly validated drug target, Spleen Tyrosine Kinase, in acute myeloid leukemia.
- 2007 Harvard Office of Educational Affairs Year-Long Grant
- To work on establishing a new branch of Camp Kesem (for children who have a parent with cancer) in Boston.
- 2007 Paul Dudley White Traveling Fellowship, Harvard Medical School
- To complete a child health screening program and research study in Lusaka, Zambia.
- 2004-5 Stanford’s HBREX Large Grant for Undergraduate Research
- Matthew Scott Laboratory at Stanford University.
- 2003-5 Howard Hughes Undergraduate Research Opportunities Grant
- Major Grant for Honor’s Thesis research in the Developmental Biology Laboratory of Dr. Matthew Scott at Stanford University.