CRISPulator aids design of genetic screens

CRISPulator Kampmann Lab

CRISPR-based genetic screens are a powerful technology to elucidate disease mechanisms and identify potential therapeutic strategies. However, the experimental design of a successful screen remains a challenge. Graduate student Tamas Nagy and Martin Kampmann developed a simulation tool for these screens, termed CRISPulator, which helps researchers to optimize the experimental parameters of different types of CRISPR-based screens. CRISPulator uncovered new rules for optimal screen design. The research was published in an article in BMC Bioinformatics:

Nagy T and Kampmann M (2017) CRISPulator: a discrete simulation tool for pooled genetic screens. BMC Bioinformatics 18:347

The software is freely available online: