
Sean.Jiang@ucsf.edu
he/him/his
Postdoctoral Fellow
Education
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Ph.D. Molecular Biology, University of California, Los Angeles (2023)
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B.Sc. Biochemistry, McGill University (2018)
Awards & Honors
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Dissertation Year Fellowship, UCLA (2023)
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Brain Diseases Award, University of Zurich (UZH) Foundation (2023)
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Life Science Dean’s Excellence Award, UCLA (2022)
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Whitcome Pre-Doctoral Fellowship in Molecular Biology, UCLA (2021, 2022)
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Audree V. Fowler Fellowships in Protein Science, UCLA (2021)
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NSERC Undergraduate Student Research Award (2017)
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Keyfitz Scholar, McGill University (2015-2018)
Research Interests
In my PhD, I studied the structures and biochemical properties of amyloid fibrils that underlie neurodegenerative diseases. Now, I am excited to use stem cell models and transcriptomic tools to advance our understanding of cellular mechanisms that drive protein aggregation and pathogenesis.
Selected Publications
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Hou, K., Ge, P., Sawaya, M.R., Dolinsky, J.L., Yang, Y., Jiang, Y.X., Lutter, L., Boyer, D.R., Cheng, X., Pi, J., Zhang, J., Lu, J., Yang, S., Yu, Z., Feigon, J., Eisenberg, D.S. How short peptides can disassemble ultra-stable tau fibrils extracted from Alzheimer’s disease brain by a strain-relief mechanism. BioRxiv (2025) https://doi.org/10.1101/2024.03.25.586668
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Tayeb-Fligelman, E., Bowler, J.T., Tai, C.E., Sawaya, M.R., Jiang, Y.X., Garcia, G., Griner, S., Cheng, X., Salwinski, L., Lutter, L., Seidler, P.M., Lu, J., Rosenberg, G.M., Hou, K., Abskharon, R., Pan, H., Zee, C., Boyer, D.R., Li, Y., Anderson, D.H., Murray, K.A., Falcon, G., Cascio, D., Saelices, L., Damoiseaux, R., Arumugaswami, V., Guo, F., Eisenberg, D.S. Low complexity domains of the nucleocapsid protein of SARS-CoV-2 form amyloid fibrils. Nature Communications 14, 2379 (2023)
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Jiang, Y.X.*, Cao, Q.*, Sawaya, M.R., Abskharon, R., Ge, P., DeTure, M., Dickson, D.W., Fu, J.Y., Ogorzalek Loo, R.R., Loo, J.A., Eisenberg, D.S. Amyloid fibrils in disease FTLD-TDP are composed of TMEM106B not TDP-43. Nature 605, 304–309 (2022)
Other Interests
I love running, hiking, playing soccer, and exploring the food scene in SF!