[email protected]
he/him/his
Postdoctoral Fellow
Education
- Ph.D. Molecular Biology, University of California, Los Angeles (2023)
- B.Sc. Biochemistry, McGill University (2018)
Awards & Honors
- Dissertation Year Fellowship, UCLA (2023)
- Brain Diseases Award, University of Zurich (UZH) Foundation (2023)
- Life Science Dean’s Excellence Award, UCLA (2022)
- Whitcome Pre-Doctoral Fellowship in Molecular Biology, UCLA (2021, 2022)
- Audree V. Fowler Fellowships in Protein Science, UCLA (2021)
- NSERC Undergraduate Student Research Award (2017)
- Keyfitz Scholar, McGill University (2015-2018)
Research Interests
In my PhD, I studied the structures and biochemical properties of amyloid fibrils that underlie neurodegenerative diseases. Now, I am excited to use stem cell models and transcriptomic tools to advance our understanding of cellular mechanisms that drive protein aggregation and pathogenesis.
Selected Publications
- Tayeb-Fligelman, E., Bowler, J.T., Tai, C.E., Sawaya, M.R., Jiang, Y.X., Garcia, G., Griner, S., Cheng, X., Salwinski, L., Lutter, L., Seidler, P.M., Lu, J., Rosenberg, G.M., Hou, K., Abskharon, R., Pan, H., Zee, C., Boyer, D.R., Li, Y., Anderson, D.H., Murray, K.A., Falcon, G., Cascio, D., Saelices, L., Damoiseaux, R., Arumugaswami, V., Guo, F., Eisenberg, D.S. Low complexity domains of the nucleocapsid protein of SARS-CoV-2 form amyloid fibrils. Nature Communications 14, 2379 (2023). PMID 37185252.
- Jiang, Y.X.*, Cao, Q.*, Sawaya, M.R., Abskharon, R., Ge, P., DeTure, M., Dickson, D.W., Fu, J.Y., Ogorzalek Loo, R.R., Loo, J.A., Eisenberg, D.S. Amyloid fibrils in disease FTLD-TDP are composed of TMEM106B not TDP-43. Nature 605, 304–309 (2022)
- Jiang YX & Eisenberg DS. To What Extent is Anfinsen’s Thermodynamic Hypothesis Consistent with the Formation and Polymorphism of Amyloid Fibrils? Journal of Molecular Biology, 169364 (2025). PMID 40750093.
- Rosenberg GM, Murray KA, Sawaya MR, Jiang YX, Geschwind DH, Eisenberg DS. Genetic and structural aspects of amyloid diseases. Science Translational Medicine 17, 818 (2025). PMID 41032625.
- Hou K, Ge P, Sawaya, MR, Lutter L, Dolinsky JL, Yang Y, Jiang YX, Boyer DR, Cheng X, Pi J, Zhang J, Lu J, Abskharon R, Yang S, Yu Z, Feigon J, Eisenberg DS. How short peptides disassemble tau fibrils in Alzheimer’s disease. Nature 644, 1020–1027 (2025). PMID 40634605.
Other Interests
I love running, hiking, playing soccer, and exploring the food scene in SF!