The Kampmann lab develops and applies innovative technologies to understand cellular and molecular mechanisms of human diseases, and to discover new therapeutic strategies. A major focus of our research are neurodegenerative and neuropsychiatric diseases.
We have pioneered a CRISPR-based functional genomics platform in human iPSC-derived neurons, glia and 3D assembloids, which enables genome-wide modifier screens of disease-relevant cell biology in patient-derived cells.
We use biochemistry, biophysics and cell biology to test mechanistic hypotheses generated by our functional genomics platform.
Major research questions are:
- How do different human cell types respond to stress?
- Which molecular mechanisms underlie the selective vulnerability of specific subtypes of neurons to stress and disease?
- What controls protein aggregation in neurons, and why is it toxic?
- How is dysfunction of different cellular processes (neuronal activity, protein homeostasis, autophagy, endolysosomal trafficking, mitochondria) coupled in neurodegeneration?
- What are the mechanisms by which disease-associated genetic variants cause brain diseases?
- What controls beneficial and toxic functions of astrocytes and microglia in disease?