Kunal Shroff

Kunal Shroff, Kampmann Lab

[email protected]
he/him/his
MSTP Student, Neuroscience Program

 

Education

BS in Neuroscience and Chemistry with a concentration in Biochemistry, Duke University

 

Honors and Awards

  • Duke Department of Chemistry Award, 2020
  • Duke Outstanding Senior Thesis in Neuroscience, 2020
  • Harvard-Amgen Scholar, 2019
  • Goldwater Scholarship, 2019
  • Intel Science Talent Search, 3rd place Basic Science, 2016

 

Research Experience

  • Calakos Lab, Department of Neurobiology, Duke University (2016-2020)
    • Led a quantitative proteomics project to determine subcellular compartment-specific defects under basal and stressed conditions
  • Murthy Lab, Department of Molecular and Cellular Biology, Harvard University (2019)
    • Identified novel mitral and tufted cell-type-specific protein markers using scRNA-seq cluster analysis and in situ antibody staining
  • Beese Lab, Department of Biochemistry, Duke University (2018)
    • Optimized novel antifungal farnesyltransferase inhibitors via in silico molecular modeling and in vitro enzyme kinetics experiments
  • Choy Lab, Department of Biology, The Catholic University of America (2014-2016)
    • Led a research project studying the effects of huntingtin on genomic instability in S. cerevisiae 
    • Established data analysis methods for high-throughput screens studying the role of sirtuins in aging and the effect of metabolic conditions on cellular metabolism pathways

 

Publications

  • Shroff, K., Caffall, Z. F., & Calakos, N. (2021). DYT-TOR1A subcellular proteomics reveals selective vulnerability of the nuclear proteome to cell stress. Neurobiology of disease, 158, 105464.
  • Choy, J. S., Qadri, B., Henry, L., Shroff, K., Bifarin, O., & Basrai, M. A. (2016). A genome-wide screen with nicotinamide to identify sirtuin-dependent pathways in saccharomyces cerevisiae. G3: Genes, Genomes, Genetics, 6(2), 485-494.

 

Research Interests

Synapse loss is highly correlated with clinical dementia symptoms and neurodegenerative conditions, such as Alzheimer’s disease. Much of this loss has been associated with microglial synaptic pruning. I am interested in using functional genomics to study the molecular mechanisms underlying synaptic pruning, as well as the neuron-microglia interactions that regulate these mechanisms.

 

Interests

Hiking, Baking, Basketball, Board Games