(Click here for all publications)
- Samelson AJ, Ariqat N, McKetney J, Rohanitazangi G, Parra Bravo C, Bose RS, Travaglini KJ, Lam VL, Goodness D, Ta T, Dixon G, Marzette E, Jin J, Tian R, Tse E, Abskharon R, Pan HS, Carroll EC, Lawrence RE, Gestwicki JE, Rexach JE, Eisenberg DS, Kanaan NM, Southworth DR, Gross JD, Gan L, Swaney DL, Kampmann M. (2026) CRISPR screens in iPSC-derived neurons reveal principles of tau proteostasis. Cell 189(5):1517-1534.
- Parker Grosjean, Kaivalya Shevade, Cuong Nguyen, Sarah Ancheta, Karl Mader, Ivan Franco, Seok-Jin Heo, Greyson Lewis, Dehua Zhao, Bhairavi Tolani, Steven Boggess, Angelique Di Domenico, Erik Ullian, Shawn Shafer, Adam Litterman, Laralynne Przybyla, Michael J. Keiser, Jamie Ifkovits, Adam Yala & Martin Kampmann (2025) Network-aware self-supervised learning enables high-content phenotypic screening for genetic modifiers of neuronal activity dynamics. Nature Machine Intelligence 7, 2009–2025.
- Ramani B, Rose IVL, Teyssier N, Pan A, Danner-Bocks S, Sanghal T, Yadanar L, Tian R, Ma K, Palop JJ, Kampmann M. (2025) CRISPR screening by AAV episome-sequencing (CrAAVe-seq): a scalable cell-type-specific in vivo platform uncovers neuronal essential genes. Nature Neuroscience 28(10):2129-2140.
- Teter OM, McQuade A, Hagan V, Liang W, Dräger NM, Sattler SM, Holmes BB, Castillo VC, Papakis V, Leng K, Boggess S, Nowakowski TJ, Wells J, Kampmann M. (2025) CRISPRi-based screen of autism spectrum disorder risk genes in microglia uncovers roles of ADNP in microglia endocytosis and synaptic pruning. Molecular Psychiatry 30(9):4176-4193.
- Li E, Benitez C, Boggess SC, Koontz M, Rose IVL, Martinez D, Dräger N, Teter OM, Samelson AJ, Pierce N, Ullian EM, Kampmann M. CRISPRi-based screens in iAssembloids to elucidate neuron-glia interactions. Neuron 113(5):701-718.
- Leng, K.*, Rooney, B.*, McCarthy, F., Xia, W., Rose, I. V. L., Bax, S., Chin, M., Fathi, S., Herrington, K. A., Leonetti, M., Kao, A., Fancy, S. P. J., Elias, J. E., & Kampmann, M. (2024). mTOR activation induces endolysosomal remodeling and nonclassical secretion of IL-32 via exosomes in inflammatory reactive astrocytes. Journal of Neuroinflammation, 21(1), 198.
- Kampmann M. (2024). Molecular and cellular mechanisms of selective vulnerability in neurodegenerative diseases. Nature Reviews Neuroscience, 25(5), 351–371.
- Leng K, Rose IVL, Kim H, Xia W, Romero-Fernandez W, Rooney B, Koontz M, Li E, Ao Y, Wang S, Krawczyk M, Tcw J, Goate A, Zhang Y, Ullian EM, Sofroniew MV, Fancy SPJ, Schrag MS, Lippmann ES, Kampmann M (2022) CRISPRi screens in human iPSC-derived astrocytes elucidate regulators of distinct inflammatory reactive states. Nature Neuroscience 25(11):1528-1542.
- Cooper YA, Teyssier N, Dräger NM, Guo Q, Davis JE, Sattler SM, Yang Z, Patel A, Wu S, Kosuri S, Coppola G, Kampmann M, Geschwind DH (2022) Functional regulatory variants implicate distinct transcriptional networks in dementia. Science 377(6608):eabi8654.
- Dräger NM, Sattler SM, Huang CT, Teter OM, Leng K, Hashemi SH, Hong J, Aviles G, Clelland CD, Zhan L, Udeochu JC, Kodama L, Singleton AB, Nalls MA, Ichida J, Ward ME, Faghri F, Gan L, Kampmann M (2022) A CRISPRi/a platform in human iPSC-derived microglia uncovers regulators of disease states. Nature Neuroscience 25(9):1149-1162.
- Tian R, Abarientos A, Hong J, Hashemi SH, Yan R, Dräger N, Leng K, Nalls MA, Singleton AB, Xu K, Faghri F, Kampmann M (2021) Genome-wide CRISPRi/a screens in human neurons link lysosomal failure to ferroptosis. Nature Neuroscience 24(7):1020-1034.
- Leng K*, Li E*, Eser R, Piergies A, Sit R, Tan M, Neff N, Li SH, Rodriguez RD, Suemoto CK, Leite REP, Ehrenberg AJ, Pasqualucci CA, Seeley WW, Spina S, Heinsen H, Grinberg LT, Kampmann M (2021). Molecular characterization of selectively vulnerable neurons in Alzheimer's disease. Nature Neuroscience 24(2):276-287.
- Kampmann M (2020) CRISPR-based functional genomics for neurological disease. Nature Reviews Neurology 16(9):465-480.
- Guo X, Aviles G, Liu Y, Tian R, Unger BA, Lin YT, Wiita AP, Xu K, Correia MA, Kampmann M (2020) Mitochondrial stress is relayed to the cytosol by an OMA1-DELE1-HRI pathway. Nature 579(7799):427-432.
- Newberry RW, Leong JT, Chow ED, Kampmann M*, DeGrado WF* (2020) Deep mutational scanning reveals the structural basis for α-synuclein activity. Nat Chem Biol 16(6):653-659. *Corresponding authors.
- Chen JJ, Nathaniel DL, Raghavan P, Nelson M, Tian R, Tse E, Hong JY, See SK, Mok SA, Hein MY, Southworth DR, Grinberg LT, Gestwicki JE, Leonetti MD, Kampmann M (2019). Compromised function of the ESCRT pathway promotes endolysosomal escape of tau seeds and propagation of tau aggregation. J Biol Chem 294(50):18952-18966
- Tian R, Gachechiladze MA, Ludwig CH, Laurie MT, Hong JY, Nathaniel D, Prabhu AV, Fernandopulle MS, Patel R, Abshari M, Ward ME, Kampmann M (2019). CRISPR Interference-Based Platform for Multimodal Genetic Screens in Human iPSC-Derived Neurons Neuron 104(2):239-255.
- Acosta-Alvear D, Cho MY, Wild T, Buchholz TJ, Lerner AG, Simakova O, Hahn J, Korde N, Landgren O, Maric I, Choudhary C, Walter P, Weissman JS, Kampmann M (2015) Paradoxical resistance of multiple myeloma to proteasome inhibitors by decreased levels of 19S proteasomal subunits. eLife 4:e08153
- Gilbert LA, Horlbeck MA, Adamson B, Villalta JE, Chen Y, Whitehead EH, Guimaraes C, Panning B, Ploegh HL, Bassik MC, Qi LS, Kampmann M*, Weissman JS* (2014). Genome-scale CRISPR-mediated control of gene repression and activation. Cell 159(3): 647-661. *Corresponding authors.
- Kampmann M, Bassik MC and Weissman JS (2013) Integrated platform for genome-wide screening and construction of high-density genetic interaction maps in mammalian cells. Proceedings of the National Academy of Sciences 110(25): E2317-26.
- Bassik MC*, Kampmann M*, Lebbink RJ, Wang S, Hein MY, Poser I, Weibezahn J, Horlbeck MA, Mann M, Hyman AA, LeProust EM, McManus MT and Weissman JS (2013) A Systematic Mammalian Genetic Interaction Map Reveals Pathways Underlying Ricin Susceptibility. Cell, 152:909-22. *Equal contribution and corresponding authors.