(Click here for all publications)
Neurodegenerative Diseases
- Leng K, Rose IVL, Kim H, Xia W, Romero-Fernandez W, Rooney B, Koontz M, Li E, Ao Y, Wang S, Krawczyk M, Tcw J, Goate A, Zhang Y, Ullian EM, Sofroniew MV, Fancy SPJ, Schrag MS, Lippmann ES, Kampmann M (2022) CRISPRi screens in human iPSC-derived astrocytes elucidate regulators of distinct inflammatory reactive states. Nature Neuroscience 25(11):1528-1542.
- Cooper YA, Teyssier N, Dräger NM, Guo Q, Davis JE, Sattler SM, Yang Z, Patel A, Wu S, Kosuri S, Coppola G, Kampmann M, Geschwind DH (2022) Functional regulatory variants implicate distinct transcriptional networks in dementia. Science 377(6608):eabi8654.
- Dräger NM, Sattler SM, Huang CT, Teter OM, Leng K, Hashemi SH, Hong J, Aviles G, Clelland CD, Zhan L, Udeochu JC, Kodama L, Singleton AB, Nalls MA, Ichida J, Ward ME, Faghri F, Gan L, Kampmann M (2022) A CRISPRi/a platform in human iPSC-derived microglia uncovers regulators of disease states. Nature Neuroscience 25(9):1149-1162.
- Tian R, Abarientos A, Hong J, Hashemi SH, Yan R, Dräger N, Leng K, Nalls MA, Singleton AB, Xu K, Faghri F, Kampmann M (2021) Genome-wide CRISPRi/a screens in human neurons link lysosomal failure to ferroptosis. Nature Neuroscience 24(7):1020-1034.
- Leng K*, Li E*, Eser R, Piergies A, Sit R, Tan M, Neff N, Li SH, Rodriguez RD, Suemoto CK, Leite REP, Ehrenberg AJ, Pasqualucci CA, Seeley WW, Spina S, Heinsen H, Grinberg LT, Kampmann M (2021). Molecular characterization of selectively vulnerable neurons in Alzheimer's disease. Nature Neuroscience 24(2):276-287.
- Kampmann M (2020) CRISPR-based functional genomics for neurological disease. Nat Rev Neurol. 10.1038/s41582-020-0373-z. doi:10.1038/s41582-020-0373-z
- Newberry RW, Leong JT, Chow ED, Kampmann M*, DeGrado WF* (2020) Deep mutational scanning reveals the structural basis for α-synuclein activity. Nat Chem Biol 16(6):653-659. *Corresponding authors.
- Chen JJ, Nathaniel DL, Raghavan P, Nelson M, Tian R, Tse E, Hong JY, See SK, Mok SA, Hein MY, Southworth DR, Grinberg LT, Gestwicki JE, Leonetti MD, Kampmann M (2019). Compromised function of the ESCRT pathway promotes endolysosomal escape of tau seeds and propagation of tau aggregation. J Biol Chem 294(50):18952-18966
Stress responses / Proteostasis
- Guo X, Aviles G, Liu Y, Tian R, Unger BA, Lin YT, Wiita AP, Xu K, Correia MA, Kampmann M (2020) Mitochondrial stress is relayed to the cytosol by an OMA1-DELE1-HRI pathway. Nature 579(7799):427-432.
- Acosta-Alvear D, Cho MY, Wild T, Buchholz TJ, Lerner AG, Simakova O, Hahn J, Korde N, Landgren O, Maric I, Choudhary C, Walter P, Weissman JS, Kampmann M (2015) Paradoxical resistance of multiple myeloma to proteasome inhibitors by decreased levels of 19S proteasomal subunits. eLife 4:e08153
Functional genomics technology
- Leng K, Rose IVL, Kim H, Xia W, Romero-Fernandez W, Rooney B, Koontz M, Li E, Ao Y, Wang S, Krawczyk M, Tcw J, Goate A, Zhang Y, Ullian EM, Sofroniew MV, Fancy SPJ, Schrag MS, Lippmann ES, Kampmann M (2022) CRISPRi screens in human iPSC-derived astrocytes elucidate regulators of distinct inflammatory reactive states. Nature Neuroscience 25(11):1528-1542.
- Dräger NM, Sattler SM, Huang CT, Teter OM, Leng K, Hashemi SH, Hong J, Aviles G, Clelland CD, Zhan L, Udeochu JC, Kodama L, Singleton AB, Nalls MA, Ichida J, Ward ME, Faghri F, Gan L, Kampmann M (2022) A CRISPRi/a platform in human iPSC-derived microglia uncovers regulators of disease states. Nature Neuroscience 25(9):1149-1162.
- Tian R, Abarientos A, Hong J, Hashemi SH, Yan R, Dräger N, Leng K, Nalls MA, Singleton AB, Xu K, Faghri F, Kampmann M (2021) Genome-wide CRISPRi/a screens in human neurons link lysosomal failure to ferroptosis. Nature Neuroscience 24(7):1020-1034.
- Tian R, Gachechiladze MA, Ludwig CH, Laurie MT, Hong JY, Nathaniel D, Prabhu AV, Fernandopulle MS, Patel R, Abshari M, Ward ME, Kampmann M (2019). CRISPR Interference-Based Platform for Multimodal Genetic Screens in Human iPSC-Derived Neurons Neuron 104(2):239-255.
- Gilbert LA, Horlbeck MA, Adamson B, Villalta JE, Chen Y, Whitehead EH, Guimaraes C, Panning B, Ploegh HL, Bassik MC, Qi LS, Kampmann M*, Weissman JS* (2014). Genome-scale CRISPR-mediated control of gene repression and activation. Cell 159(3): 647-661. *Corresponding authors.
- Kampmann M, Bassik MC and Weissman JS (2013) Integrated platform for genome-wide screening and construction of high-density genetic interaction maps in mammalian cells. Proceedings of the National Academy of Sciences 110(25): E2317-26.
- Bassik MC*, Kampmann M*, Lebbink RJ, Wang S, Hein MY, Poser I, Weibezahn J, Horlbeck MA, Mann M, Hyman AA, LeProust EM, McManus MT and Weissman JS (2013) A Systematic Mammalian Genetic Interaction Map Reveals Pathways Underlying Ricin Susceptibility. Cell, 152:909-22. *Equal contribution and corresponding authors.