
he/him/his
Neuroscience PhD Student
Education
- PhD candidate in Neuroscience, UCSF
- MS, Neuroscience, Johns Hopkins, 2018
- BS, Neuroscience and Cognitive Science, Johns Hopkins, 2018
Research Experience
- Liddelow Lab, NYU Langone Medical Center, 2018-20
- Astrocyte reactivity in neurodegenerative disease
- Kano Lab, Johns Hopkins University School of Medicine, 2016-18
- Neuroimmune signaling in mouse behavior & neuroinflammation
- Hyde Group, Lieber Institute for Brain Development, 2014-15
- Postmortem human brain processing for brain bank
Selected Honors/Awards
- Hillblom/BARI Graduate Fellowship Award (2024-25)
- Poster Award, Gordon Research Conf. Neurobiology of Brain Disorders (2022, 2024)
- CIRM Scholars Research Training Fellowship Award (2021-23)
- NIH T32 Fellowship Award for Predoctoral Training in Neurobiology (2020-21)
- Emily and Thomas Meren Award for Outstanding Achievement in Neuroscience (2018)
Selected Talks
- Gordon Research Seminar: Neurobiology of Brain Disorders (2024)
- Cold Spring Harbor Laboratory Meeting on Genome Engineering: CRISPR Frontiers (2023)
- Society for Neuroscience, Nano-symposium (2022)
Selected Publications
Full list of publications on Google Scholar
- *Ramani B, *Rose IVL, Teyssier N, Pan A, Danner-Bocks S, Sanghal T, Yadanar L, Tian R, Ma K, Palop JJ, & Kampmann M (2025). CRISPR screening by AAV episome-sequencing (CrAAVe-seq) is a highly scalable cell type-specific in vivo screening platform. Accepted in principle at Nat Neurosci. Preprint PMID: 37398301.
- Li E, Benitez C, Boggess S, Koontz M, Rose IVL, Dräger N, Teter O, Samelson AJ, Ullian E, & Kampmann M. CRISPRi-based screens in iAssembloids to elucidate neuron-glia interactions (2025). Neuron. PMID: 39814010.
- *Leng K, *Rooney B, McCarthy F, Xia W, Rose IVL, Bax S, Chin M, Fathi S, Herrington KA, Leonetti M, Kao AW, Fancy SPJ, Elias JE, & Kampmann M (2024). mTOR activation induces endolysosomal remodeling and nonclassical secretion of IL-32 via exosomes in inflammatory reactive astrocytes. J. Neuroinflam. PMID: 39118084.
- Pantazis CB, … Rose IVL, … Kampmann M, … & Merkle FT (93 authors) (2022). A reference induced pluripotent stem cell line for large-scale collaborative studies. Cell Stem Cell. PMID: 36459969.
- Kleffman K, Levinson G, Rose IVL, … Liddelow SA, Schneider RJ, & Hernando E (30 authors) (2022). Melanoma-secreted Amyloid Beta Suppresses Neuroinflammation and Promotes Brain Metastasis. Cancer Discovery. PMID: 35262173.
- Hasel P, Rose IVL, Sadick JS, Kim RD, Liddelow SA (2021). Neuroinflammatory astrocyte subtypes in the mouse brain. Nat Neurosci, PMID: 34413515.
- Barbar L, Jain T, Zimmer M, Kruglikov I, Sadick JS, Wang M, Kalpana K, Rose IVL, Burstein SR, Rusielewicz T, Nijsure M, Guttenplan KA, di Domenico A, Croft G, Zhang B, Nobuta H, Hébert JM, Liddelow SA, Fossati V (2020). CD49f is a novel marker of functional and reactive human iPSC derived astrocytes. Neuron, PMID: 32485136.
- Hartmann K, Sepulveda-Falla D, Rose IVL, Madore C, Muth C, Matschke J, Butovsky O, Liddelow SA, Glatzel M, Krasemann S (2019). Complement 3+-astrocytes are highly abundant in prion diseases, but their abolishment led to an accelerated disease course and early dysregulation of microglia. Acta Neuropathol Comm, PMID: 31118110.
- Kano SI, Dohi E, Rose IVL (2018). Extracellular Vesicles for Research on Psychiatric Disorders. Schizophrenia Bulletin, PMID: 30239909.
- Dohi E, Choi EY, Rose IVL, Murata A, Chow S, Niwa M, Kano SI (2017). Behavioral Changes in mice lacking interleukin-33. eNeuro, PMID: 29379874.
Research Interests
I study the molecular mechanisms of astrocyte reactivity and neuronal survival in neurodegeneration using functional genomics. To do this, I co-developed a new technique called CrAAVe-seq which lets us transduce large libraries of sgRNAs directly in the mouse brain to perturb genes in a highly scalable and cell type-specific manner. This has let us discover neuron essential genes in several molecularly defined neuronal subpopulations. I’m currently applying this technique and modifying it to let me uncover mechanisms regulating astrogliosis.
Other Interests
Biking, board games, hiking, linguistics, architecture & urban planning, public transit infrastructure, watching tugboats on the bay, the quest to find the best almond croissant in SF