Xiaoyan Guo, PhD

Xiaoyan Guo, Kampmann Lab

[email protected]
Postdoctoral Fellow



BS (2002-2006) from Beijing Normal University

PhD (2008-2014) from Texas A&M University


  • Zhang L, Gualberto D, Guo X, Correa P, Jee C, Garcia L. (2015) TMC-1 attenuates C. elegans development and sexual behavior in a foreign food environment. Nature Communication 19;6:6345
  • Guo X, Garcia L. (2014) SIR-2.1 integrates metabolic homeostasis with the reproductive neuromuscular excitability in early aging male C. elegans. eLife 2014; 3: e01730.
  • Guo X, Navetta A, Gualberto DG and Garci­a LR (2012) Behavioral decay in aging male C. elegans correlates with increased cell excitability Neurobiol Aging 33:1483.e5-23
  • Liu Y, LeBeouf B, Guo X, Correa PA, Gualberto DG, Lints R and Garcia LR (2011) A cholinergic-regulated circuit coordinates the maintenance and bi-stable states of a sensory-motor behavior during Caenorhabditis elegans male copulation. PLoS Genet 7:e1001326
  • LeBoeuf B, Guo X and Garcia LR (2011) The effects of transient starvation persist through direct interactions between CaMKII and ether-a-go-go K+ channels in C. elegans males. Neurosci 175:1-17
  • Liu J, Wu Q, He D, Ma T, Du L, Dui W, Guo X and Jiao R. (2011) Drosophila sbo regulates lifespan through its function in the synthesis of coenzyme Q in vivo. J. Genet. Genomics, 38: 225-234.
  • Song Y, He F, Xie G, Guo X, Xu Y, Chen Y, Liang X, Stagljar I, Egli D, Ma J, and Jiao R. (2007) Chromatin assembly factor 1 is essential for Drosophila development and epigenetic memory. Dev Biol, 311: 213–222.
  • Goncalves J*, Wan Y*, Guo X*Rha K, LeBoeuf B, ZhangL, EstlerK, Garcia LR (2020) Succinate dehydrogenase-regulated phosphoenolpyruvate carboxykinase sustains copulation fitness in aging C. elegans males. iScience 23: 4 (*equal contributions)
  • Guo X, Aviles G, Liu Y, Tian R, Unger B, Lin Y, Wiita A, Xu K, Correia MA, Kampmann M (2020) Mitochondrial stress is relayed to the cytosol by an OMA1–DELE1–HRI pathway. Nature 579: 427-432.

Research Experience:

  • 2006-2008 Research assistant in Dr. Renjie Jiao’s Lab at the Institute of Biophysics of Chinese Academy of Sciences, Beijing, China
    Project: Functional study of chromatin assembly factor 1(CAF1) in Drosophila.
  • 2008-2014 PhD Candidate in Dr. Luis Rene Garcia’s Lab at Texas A&M University
    Project: Mechanisms of behavioral deterioration in early aging male C. elegans
  • 2014-2015 Postdoc in Dr. Luis Rene Garcia’s Lab at Texas A&M University
    Project: The link between phosphoenolpyruvate carboxykinase (pck-2) and male mating behavior during aging in C. elegans.

Awards and honors:

  • Roozbeh Arianpour distinguished graduate student award, TAMU (2014)
  • The excellent undergraduate student honored by Beijing Normal University (2006)

Research interests:

Parkinson’s disease (PD) is the second most common neurodegenerative disease and the most prevalent progressive movement disorder among the elderly. So far, there is no cure for this disease, due to our lack of a mechanistic understanding necessary for developing effective therapies. Human genetics and studies in experimental model systems have linked both mitochondrial dysfunction and alpha-synuclein aggregation to PD. Although there are several lines of evidence showing that these two interact with each other, it is still mysterious how mitochondrial dysfunction promotes alpha-synuclein aggregation and, vice versa, how alpha-synuclein aggregation leads to mitochondrial dysfunction. My research interest is to understand the interplay between mitochondrial dysfunction and alpha-synuclein aggregation in PD.

Other interests:

Hiking, jogging and swim, hopefully SCUBA diving trips