Emmy Li

Education:

• Ph.D. student in the Biomedical Sciences program, University of California, San Francisco.
• B.A. in Neuroscience, Wellesley College, Wellesley, MA

Research Experience:

• Greenberg Lab, Neurobiology Department, Harvard Medical School (Boston, MA) - studied the mechanism by which the Methyl-CpG-binding protein 2 (MeCP2) regulates transcription.
• Beltz Lab, Neuroscience Program, Wellesley College (Wellesley, MA) - Investigated the source of neuronal precursors in the crayfish, Procambarus clarkii.

Publications (by legal name):

• Benton, J. L., Kery, R., Li, J., Noonin, C., Soderhall, I., & Beltz, B. S. (2014). Cells from the immune system generate adult-born neurons in crayfish. Dev Cell, 30(3), 322-333. doi:0.1016/j.devcel.2014.06.016
• Beltz, B. S., Cockey, E. L., Li, J., Platto, J. F., Ramos, K. A., & Benton, J. L. (2015). Adult neural stem cells: Long-term self-renewal, replenishment by the immune system, or both? Bioessays. 2015 May;37(5):495-501. doi: 10.1002/bies.201400198.
• Lisa D. Boxer,* William Renthal,* Alexander W. Greben, Tess Whitwam, Andrew Silberfeld, Hume Stroud, Emmy Li, Marty G. Yang, Benyam Kinde, Eric C. Griffith, Boyan Bonev, Michael E. Greenberg. MeCP2 Represses the Rate of Transcriptional Initiation of Highly Methylated Long Genes. Mol. Cell 2020 Jan 16;77(2):294-309.e9. doi: 10.1016/j.molcel.2019.10.032.
• Mayer, S., Chen, J., Velmeshev, D., Mayer, A., Eze, U. C., Bhaduri, A., Cunha, C.E., Jung, D., Arjun, A., Li, E., ... Kriegstein, A. R. (2019). Multimodal Single-Cell Analysis Reveals Physiological Maturation in the Developing Human Neocortex. Neuron. https://doi.org/10.1016/j.neuron.2019.01.02
• William Renthal,* Lisa D. Boxer,* Sinisa Hrvatin, Emmy Li, Andrew Silberfeld, M. Aurel Nagy, Eric C. Griffith, Thomas Vierbuchen and Michael E. Greenberg. Characterization of human mosaic Rett syndrome brain tissue by single-nucleus RNA sequencing. Nat. Neurosci. 2018 Dec;21(12):1670-1679. doi: 10.1038/s41593-018-0270-6.

Honors and Awards:

• Hubel Thesis Writing Prize, Neuroscience Program, Wellesley College (2015)
• Phi Beta Kappa, Wellesley College (2015)
• NDSEG Fellowship (2019)
• Kampmann Lab Twitter Manager

The APOE-e4 allele of the apolipoprotein E (APOE) gene is the major known genetic risk factor for late-onset Alzheimer's disease. However, the relationship between APOE4 expression and neurodegenerative disease is still unclear. My research interest lies in taking a functional genomics approach to investigate the association between APOE4 and neurodegeneration in iPSC derived neuronal and glial cells.

 

Kayaking, exploring museums & aquariums, puzzling and baking bread. No more traveling.