Ruilin Tian, PhD

Ruilin Tian, Kampmann lab, UCSF

[email protected]
he/him/his
Postdoctoral Fellow

 

Education:

  • 2015 – 2020 Ph.D. in Biophysics Adviser: Dr. Martin Kampmann
    University of California, San Francisco, CA, USA
     
  • 2011 ‑ 2015 B.S. in Biological Sciences
    ​Peking University, Beijing, China

 

Research Experience:

  • Aug. 2016 – Jun. 2020  Kampmann laboratory, UCSF
    • Developed CRISPR-based functional genomics platforms in human iPSC-derived neurons.
    • Uncovered genes regulating neuronal redox homeostasis and oxidative stress response through genome-wide CRISPR screens.
      ​
  • Nov. 2014 – Jul. 2015   Ou laboratory, Tsinghua University
    • Investigated genes involved in cilliogenesis in C.elegans sensory neurons
      ​
  • Jul. 2014 – Sept. 2014   Derry laboratory, University of Toronto
    • Investigated the role of CCM-3 in C. elegans germline development
       
  • Sept. 2013 – Jul. 2014   Ouyang laboratory, Peking University
    • Genome-wide study of intracellular NADPH level regulation and its impact on aging
    • Investigated the mechanism of accelerated aging in budding yeast induced by telomerase inactivation

 

Publications:

  • Semesta, K. M., Tian, R., Kampmann, M., von Zastrow, M., & Tsvetanova, N. G. (2020). A High‐throughput CRISPR Interference Screen to Dissect Functional Regulators of GPCR/cAMP Signaling. The FASEB Journal, 34(S1), 1-1.
  • Guo, X., Aviles, G., Liu, Y., Tian, R., Unger, B.A., Lin, Y.H.T., Wiita, A.P., Xu, K., Correia, M.A. and Kampmann, M., (2020). Mitochondrial stress is relayed to the cytosol by an OMA1–DELE1–HRI pathway. Nature, 579(7799), pp.427-432.
  • Tian, R., Gachechiladze, M.A., Ludwig, C.H., Laurie, M.T., Hong, J.Y., …, Ward, M.E. & Kampmann, M., (2019). CRISPR interference-based platform for multimodal genetic screens in human iPSC-derived neurons. Neuron, 10.1016/j.neuron.2019.07.014
    • Featured as a cover story in Neuron
    • Featured on the Neuron website with a video abstract
    • Featured by a Research Highlight in Nature Reviews Neuroscience
  • Ramkumar, P., Tian, R., Seyler, M., Leong, J. T., Chen, M., Choudhry, P., ... & Kampmann, M., (2019). CRISPR-based screens uncover determinants of immunotherapy response and potential combination therapy strategies. bioRxiv, 833707.
  • Torres, S.E., Gallagher, C.M., Plate, L., Gupta, M., Liem, C.R., Guo, X., Tian, R., Stroud, R.M., Kampmann, M., Weissman, J.S. and Walter, P., (2019). Ceapins block the unfolded protein response sensor ATF6α by inducing a neomorphic inter-organelle tether. eLife, 8.
  • Chen, J.J., Nathaniel, D.L., Raghavan, P., Nelson, M., Tian, R., …, and Kampmann, M., (2019). Compromised function of the ESCRT pathway promotes endolysosomal escape of tau seeds and propagation of tau aggregation. Journal of Biological Chemistry, pp.jbc-RA119.
  • Zhang, Y. J., Guo, L., ... Tian,R., … & Petrucelli, L. (2019). Heterochromatin anomalies and double-stranded RNA accumulation underlie C9orf72 poly (PR) toxicity. Science, 363(6428), eaav2606.
  • Boettcher, M., Tian, R., Blau, J. A., Markegard, E., Wagner, R. T., Wu, D., ... & McManus, M.T., (2018). Dual gene activation and knockout screen reveals directional dependencies in genetic networks. Nature biotechnology, 36(2), 170.
  • - Nature Biotechnology
  • Mavor, D., Barlow, K. A., …, Tian, R., … , Kampmann, M. & Fraser, S. J., (2018). Extending chemical perturbations of the ubiquitin fitness landscape in a classroom setting reveals new constraints on sequence tolerance. Biology open, 7(7), bio036103.
  • Pal, S., Lant, B., Yu, B., Tian, R., Tong, J., Krieger, J. R., ... & Derry, W. B. (2017). CCM-3 promotes C. elegans germline development by regulating vesicle trafficking cytokinesis and polarity. Current Biology, 27(6), 868-876.
  • Xie, Z., Jay, K.A., Smith, D.L., Zhang, Y., Liu, Z., Zheng, J., Tian, R., Li, H. and Blackburn, E.H. (2015). Early telomerase inactivation accelerates aging independently of telomere length. Cell, 160(5), pp.928-939.
  • He, C., Tsuchiyama, S.K., Nguyen, Q.T., …, Tian, R., …, Kennedy, K.B. & Polymenis, M., (2014). Enhanced longevity by ibuprofen, conserved in multiple species, occurs in yeast through inhibition of tryptophan import. PLoS genetics, 10(12), p.e1004860.

 

​Honors and Awards:

  • 2016 Tau consortium fellowship by the Tau consortium
  • 2015 Graduation with honor: Outstanding Undergraduate Award of Peking University
  • 2015 Graduation with honor: Outstanding Undergraduate Award of Beijing, China
  • 2014 National Scholarship by Chinese government
  • 2013 May Fourth Scholarship by Peking University

 

Research interests:

Developing methods for in vivo CRISPR screens to elucidate mechanisms of human neurodegenerative diseases.

 

Other interests:

Traveling, basketball, photography