Recently developed immunotherapies hold great promise for cancer patients, but we have an incomplete understanding of the factors that make immunotherapies successful, and of combination therapies that increase response to immunotherapy.
The function of mitochondria, the “powerhouse of the cell”, can be compromised in aging and disease. Dysfunctional mitochondria trigger a global cellular stress response, but how human mitochondria signal stress to the rest of the cell was unknown.
Intrinsically disordered proteins can adopt different conformation in cells. Some of these conformations fulfill beneficial functions in cells, while others are “misfolded” and can be toxic and be linked to diseases, such as neurodegenerative disease. It is very challenging to characterize the…
Our CRISPRi screening platform for iPSC-derived human neurons was published in the Oct. 23 issue of Neuron, and the beautiful artwork by Connor Ludwig was chosen for the cover: Neurons forming a volcano plot (the graph we use to show the results from a genome-wide screen).
Martin Kampmann was one of four recipients of the inaugural "Excellence in Graduate Student Mentoring Award". Along with UCSF faculty Anita Sil, Eric Huang and Matt Spitzer, he was recognized by the Biomedical Sciences (BMS) Graduate program for his mentorship, based on the nomination by students…
Prion-like spreading of tau aggregation between cells is thought to be an important mechanism by which Alzheimer’s Disease and several other neurodegenerative diseases progress. A major question is which cellular pathways mediate or counteract this process.
Avi Samelson, postdoc in the Kampmann lab, was awarded the Alzheimer’s Association’s Research Fellowship. (He declined since he recently also received the NIH Kirschstein Postdoctoral National Research Service Award.) Avi's goal is to systematically understand the factors that control disease-…
Kun Leng, an MD/PhD student in the Kampmann lab, received an F30 fellowship from the NIH National Institute on Aging (NIA/NIH). Kun has pioneered CRISPR-based functional genomics in human iPSC-derived astrocytes. In his research, he uses this technology to elucidate the mechanisms controlling…
In an article published today in Neuron (open-access preprint on bioRxiv), we present a new technology for large-scale CRISPR-based investigation of gene function in human neurons generated from induced pluripotent stem cells. We uncovered pathways that control neuronal survival…
Avi Samelson, postdoc in the Kampmann lab, received the Ruth L. Kirschstein Postdoctoral Individual National Research Service Award from the National Institute on Aging (NIA), part of the National Institutes of Health (NIH). Avi's goal is to systematically understand the factors that control…
